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Smoking Associated With Increased Risk Of Cervical Cancer Among Human Papillomavirus-Infected Women

September 18, 2002

(Journal of the National Cancer Institute) -- Current and past smoking may increase the risk of cervical cancer among women who have been infected with the human papillomavirus (HPV), according to a study in the September 18 issue of the Journal of the National Cancer Institute.

Philip E. Castle, Ph.D., of the National Cancer Institute, and his colleagues looked at the association between various risk factors and cervical cancer among 1,812 women who had tested positive for oncogenic HPV DNA. Oral contraceptive use and history of live births were not associated with the risk of cervical cancer or its precursor, cervical intraepithelial neoplasia grade 3 (CIN3). However, former and current smokers appeared to have an increased risk of cervical cancer and CIN3 compared with women who never smoked.

The authors say that future studies should examine whether biomarkers associated with smoking, such as DNA damage, are present in cervical tissue and whether such biomarkers can be detected before the development of CIN3 or cervical cancer.

 

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